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Line 12: − + − **Aperiodic components of a signal will spread out their power in all frequencies, when doing FFT it can appear as if there is oscillatory activity when in fact there is none.+ − **Band analysis, including band power ratios, are rife with potential for misinterpretation unless you break out the aperiodic components − **Changes in the aperiodic exponent or offset can mimic changes in band power − *Read through the RISE application. − **Mentoring plan is the most important single component. − **Met with Norm Taylor to discuss timing and considerations for project directions and mentors, identify successful applicants. − + + Line 28:
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→9/22
== 9/22 ==
== 9/22 ==
*Learned about [https://fooof-tools.github.io/fooof/auto_motivations/index.html FOOOF motivations].
*Reached out to Hamilton (how do you know that a worm is anesthetized)?
*Met Coby
*Met Coby
**From UCLA, now a 2nd year PhD student in Christian's lab, focusing on SWARM analysis.
**From UCLA, now a 2nd year PhD student in Christian's lab, focusing on SWARM (slow-wave analysis.
**They are getting frontal EEG data from SEEG explants and correlating LFPs and single neuron activity with SO/SW data from frontal EEG.
**They are getting frontal EEG data from SEEG explants and correlating LFPs and single neuron activity with SO/SW data from frontal EEG.
**Implanted electrodes attract glia which adhere to the electrodes and make a local inflammatory response that increases impedance and reduces data quality.
**Implanted electrodes attract glia which adhere to the electrodes and make a local inflammatory response that increases impedance and reduces data quality.
*Met w/ Talmage
*Met w/ Talmage
**BIS study that he is starting with Christian in the next few months. I should get on board.
**BIS study that he is starting with Christian in the next few months. I should get on board.
**20 years ago he licensed some PK/PD software to GE but no one bought it. A Norwegian company tried the same thing, also without success. He is now trying to get it integrated into EPIC. Is it just a marketing problem that no one wants to buy it? They've shown that it changes how people deliver anesthesia (typically they use less, specifically opioid).
**20 years ago he licensed some PK/PD software to GE but no one bought it. A Norwegian company tried the same thing, also without success. He is now trying to get it integrated into EPIC. Is it just a marketing problem that no one wants to buy it? They've shown that it changes how people deliver anesthesia (typically they use less, specifically opioid).
**He thinks the big thing that is lacking from Christian's research is volunteer studies.
**He thinks the big thing that is lacking from Christian's research is volunteer studies.
*Read through the RISE application.
**Mentoring plan is the most important single component.
**Met with Norm Taylor to discuss timing and considerations for project directions and mentors, identify successful applicants.
*Learned about [https://fooof-tools.github.io/fooof/auto_motivations/index.html FOOOF motivations]. "Fitting oscillations and 1/f"
**Aperiodic components of a signal will spread out their power in all frequencies, when doing FFT it can appear as if there is oscillatory (rhythmic) activity when in fact there is none.
**Band analysis, including band power ratios, are rife with potential for misinterpretation unless you break out the aperiodic components
**Changes in the aperiodic exponent or offset can mimic changes in band power.
*Initial assessment of feasibile/high-impact research ideas:
*Initial assessment of feasibile/high-impact research ideas:
**Depression
**Depression
***Does permissive hypercapnia improve hemodynamic stability, deepen anesthesia, and speed recovery?
***Does permissive hypercapnia improve hemodynamic stability, deepen anesthesia, and speed recovery?
***Can we make a device or repurpose an existing ventilator to help accomplish that?
***Can we make a device or repurpose an existing ventilator to help accomplish that?
*High-impact, less feasible research ideas:
*High-impact, less feasible research ideas:
**Does TIVA prevent cancer recurrence? Could be feasible if we are able to mine the data from someone else's data set.
**Does TIVA prevent cancer recurrence? Could be feasible if we are able to mine the data from someone else's data set.
**Mechanisms of anesthesia. Is it dogma that anesthesia works by disrupting neuronal circuitry? Can I disprove this by anesthetizing weird organisms?
**Mechanisms of anesthesia. Is it dogma that anesthesia works by disrupting neuronal circuitry? Can I disprove this by anesthetizing weird organisms?
**Cancer vaccine. Can we make an mRNA vaccine that increases p53 copy number. Peto's paradox. Elephants.
**Cancer vaccine. Can we make an mRNA vaccine that increases p53 copy number. Peto's paradox. Elephants.
*Low-impact, very feasible research ideas:
*Low-impact, very feasible research ideas:
**SCD-FR
**SCD-FR
**Better late than never PONV
**Better late than never PONV