1,415
edits
Changes
Jump to navigation
Jump to search
Line 1:
Line 1: − + − + − + − + + + + + + + − '''Monthly Goals:'''+ − *Meet w/ Nina+ − + − − − == 9/22 == − *Learned about [https://fooof-tools.github.io/fooof/auto_motivations/index.html FOOOF motivations]. − **Aperiodic components of a signal will spread out their power in all frequencies, when doing FFT it can appear as if there is oscillatory activity when in fact there is none. − **Band analysis, including band power ratios, are rife with potential for misinterpretation unless you break out the aperiodic components − **Changes in the aperiodic exponent or offset can mimic changes in band power − *Read through the RISE application. − **Mentoring plan is the most important single component. − **Met with Norm Taylor to discuss timing and considerations for project directions and mentors, identify successful applicants. − + + + + Line 27:
Line 26: − + − + − + + + + + + + + + + + + − + Line 40:
Line 50: + − + + − +
no edit summary
'''Annual Goals:'''
'''AY '26-'27 Goals'''
*Finish Brandon's study
*Submit a manuscript for publication
*RISE 1 application
**Meet w/ Nina
*Methohexital analysis
*Submit RISE 1 application
**Think deeply about research directions and goals
**Literature review to refine research aims
**Figure out organizational system to be more productive with research time
**Start identifying mentors
*Identify additional funding sources and apply
*Start recruiting a research team
== 9/22 ==
*Talked to Hamilton (re: how do you know that a worm is anesthetized)?
*Think deeply about research directions and goals
**Schedule another phone call on 10/2. He's interested in collaborating on a high-throughput screen in C. elegans.
*Literature review to refine research aims
*Figure out organizational system to be more productive with research time
*Met Coby
*Met Coby
**From UCLA, now a 2nd year PhD student in Christian's lab, focusing on SWARM analysis.
**From UCLA, now a 2nd year PhD student in Christian's lab, focusing on SWARM (slow-wave analysis something modulation?)
**They are getting frontal EEG data from SEEG explants and correlating LFPs and single neuron activity with SO/SW data from frontal EEG.
**They are getting frontal EEG data from SEEG explants and correlating LFPs and single neuron activity with SO/SW data from frontal EEG.
**Implanted electrodes attract glia which adhere to the electrodes and make a local inflammatory response that increases impedance and reduces data quality.
**Implanted electrodes attract glia which adhere to the electrodes and make a local inflammatory response that increases impedance and reduces data quality.
*Eric Melonakos: suggested presenting at the [https://www.grc.org/consciousness-anesthesia-and-evolutionary-biology-conference/2027/ Gordon Research Conference]. Jan 17-22 in Oxnard, CA (near Santa Barbara). Abstracts due by 12/20.
*Met w/ Talmage
*Met w/ Talmage
**BIS study that he is starting with Christian in the next few months. I should get on board.
**BIS study that he is starting with Christian in the next few months. I should get on board.
**20 years ago he licensed some PK/PD software to GE but no one bought it. A Norwegian company tried the same thing, also without success. He is now trying to get it integrated into EPIC. Is it just a marketing problem that no one wants to buy it? They've shown that it changes how people deliver anesthesia (typically they use less, specifically opioid).
**20 years ago he licensed some PK/PD software to GE but no one bought it. A Norwegian company tried the same thing, also without success. He is now trying to get it integrated into EPIC. Is it just a marketing problem that no one wants to buy it? They've shown that it changes how people deliver anesthesia (typically they use less, specifically opioid).
**He thinks the big thing that is lacking from Christian's research is volunteer studies.
**He thinks the big thing that is lacking from Christian's research is volunteer studies.
*Initial assessment of feasibile/high-impact research ideas:
**He did a bunch of PD studies looking at responses to different noxious stimuli at various effect site concentrations. Still has the equipment.
**Depression
***What is the disease burden of depression in the general surgical population?
*Read through the RISE application.
**Mentoring plan is the most important single component.
**Met with Norm Taylor to discuss timing and considerations for project directions and mentors, identify successful applicants.
*Learned about [https://fooof-tools.github.io/fooof/auto_motivations/index.html FOOOF motivations]. "Fitting oscillations and 1/f"
**Aperiodic components of a signal will spread out their power in all frequencies, when doing FFT it can appear as if there is oscillatory (rhythmic) activity when in fact there is none.
**Band analysis, including band power ratios, are rife with potential for misinterpretation unless you break out the aperiodic components
**Changes in the aperiodic exponent or offset can mimic changes in band power.
*Feasibile and high-impact research ideas:
**[[Intra-op Treatment and Prophylaxis Against Depression | Depression]]
***What is the disease burden of depression in the general surgical population? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c14%7c1&Counter5=SS_view_found_complete%7c40404498%7cmedall%7cmedline%7cmed29&Counter5Data=40404498%7cmedall%7cmedline%7cmed29 BJA article] that finds 20% burden of depression in the surgical patients during the pre-op period. They also note that patients have a 2.5x higher risk of non-home discharge. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c16%7c1&Counter5=SS_view_found_complete%7c41495495%7cmedall%7cmedline%7cmed29&Counter5Data=41495495%7cmedall%7cmedline%7cmed29 2026 systematic review and meta-analysis] showing that about 1/4 of surgical cancer patients have depression. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c19%7c1&Counter5=SS_view_found_complete%7c41337802%7cmedall%7cmedline%7cmed29&Counter5Data=41337802%7cmedall%7cmedline%7cmed29 2026 Journal of Clinical Neuroscience] article showed a 4-fold increase in risk of re-operation in ACDF patients who were depressed.
***What is the incidence of post-operative depression in general surgical patients without pre-existing depression? What if they have a family or personal history of depression?
***What is the incidence of post-operative depression in general surgical patients without pre-existing depression? What if they have a family or personal history of depression?
***Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk?
***Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c2%7c1&Counter5=SS_view_found_complete%7c42657795%7cmedall%7cmedline%7cmedl&Counter5Data=42657795%7cmedall%7cmedline%7cmedl RCT happening in China right now]. Another RCT done in China with 142 cardiac surgery patients showed [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c23%7c1&Counter5=SS_view_found_complete%7c41285329%7cmedall%7cmedline%7cmed28&Counter5Data=41285329%7cmedall%7cmedline%7cmed28 significantly decreased post-operative depression] in patients who got a single dose of ketamine (0.3 mg/kg) at induction. After reviewing the first 51 results on Ovid Medline, I saved selected abstracts to Box.
**CLAN
**CLAN
***When combined with SEEG electrodes or data from Parkinson's patients with deep-brain stimulators, can we resolve temporal and spatial activity of deep subcortical structures with ICA from frontal or full EEG? [https://pubmed.ncbi.nlm.nih.gov/28575667/ steerable non-invasive DBS]
***When combined with SEEG electrodes or data from Parkinson's patients with deep-brain stimulators, can we resolve temporal and spatial activity of deep subcortical structures with ICA from frontal or full EEG? [https://pubmed.ncbi.nlm.nih.gov/28575667/ steerable non-invasive DBS]
***Does permissive hypercapnia improve hemodynamic stability, deepen anesthesia, and speed recovery?
***Does permissive hypercapnia improve hemodynamic stability, deepen anesthesia, and speed recovery?
***Can we make a device or repurpose an existing ventilator to help accomplish that?
***Can we make a device or repurpose an existing ventilator to help accomplish that?
*High-impact, less feasible research ideas:
*High-impact, less feasible research ideas:
**Does TIVA prevent cancer recurrence? Could be feasible if we are able to mine the data from someone else's data set.
**Does TIVA prevent cancer recurrence? Could be feasible if we are able to mine the data from someone else's data set.
**Does general anesthesia lead to post-op ileus and constipation?
**Does general anesthesia lead to post-op ileus and constipation?
**Mechanisms of anesthesia. Is it dogma that anesthesia works by disrupting neuronal circuitry? Can I disprove this by anesthetizing weird organisms?
**Mechanisms of anesthesia. Is it dogma that anesthesia works by disrupting neuronal circuitry? Can I disprove this by anesthetizing weird organisms? Light-emitting bacteria were anesthetized in [https://dx.doi.org/10.1093/bja/46.3.196 1974] (less light emission). There's 0 papers on anesthetizing amoeba.
**Cancer vaccine. Can we make an mRNA vaccine that increases p53 copy number. Peto's paradox. Elephants.
**Cancer vaccine. Can we make an mRNA vaccine that increases p53 copy number. Peto's paradox. Elephants.
*Low-impact, very feasible research ideas:
*Low-impact, very feasible research ideas:
**SCD-FR
**SCD-PV
**Better late than never PONV
**Better late than never PONV