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→Mechanisms of Anesthesia
*'''Are there genetic KO/KD or optogenetic tools available for location-specific inducible receptor knockdowns?'''
*'''Are there genetic KO/KD or optogenetic tools available for location-specific inducible receptor knockdowns?'''
**Optogenetics has been used to inhibit neurons ([https://scholar.googleusercontent.com/scholar.bib?q=info:E5ci0TmjTyUJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuAMnI:ACTRDVEAAAAAas-GKnJgn-bjNlsNLChcKv4my2s&scisig=ACTRDVEAAAAAas-GKgEqKyhrCyTgoY7wITcfbIk&scisf=4&ct=citation&cd=-1&hl=en Boyden] [https://scholar.googleusercontent.com/scholar.bib?q=info:5bB4NZj9XJwJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuAD4Q:ACTRDVEAAAAAas-GF4QQx1MktzR7KJjHy7lxqtc&scisig=ACTRDVEAAAAAas-GF0WwYhYzurZCN_BZ43PKYBA&scisf=4&ct=citation&cd=-1&hl=en Zhang]) and control motor responses in ''C. elegans'' ([https://scholar.googleusercontent.com/scholar.bib?q=info:DR_TtH156CwJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuATj4:ACTRDVEAAAAAas-GVj4eXZwSNxuPraJTtvvWPi4&scisig=ACTRDVEAAAAAas-GVgi34VSVojs0nt7HO_YbU68&scisf=4&ct=citation&cd=-1&hl=en Nagel])
**Optogenetics has been used to inhibit neurons ([https://scholar.googleusercontent.com/scholar.bib?q=info:E5ci0TmjTyUJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuAMnI:ACTRDVEAAAAAas-GKnJgn-bjNlsNLChcKv4my2s&scisig=ACTRDVEAAAAAas-GKgEqKyhrCyTgoY7wITcfbIk&scisf=4&ct=citation&cd=-1&hl=en Boyden] [https://scholar.googleusercontent.com/scholar.bib?q=info:5bB4NZj9XJwJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuAD4Q:ACTRDVEAAAAAas-GF4QQx1MktzR7KJjHy7lxqtc&scisig=ACTRDVEAAAAAas-GF0WwYhYzurZCN_BZ43PKYBA&scisf=4&ct=citation&cd=-1&hl=en Zhang]) and control motor responses in ''C. elegans'' ([https://scholar.googleusercontent.com/scholar.bib?q=info:DR_TtH156CwJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuATj4:ACTRDVEAAAAAas-GVj4eXZwSNxuPraJTtvvWPi4&scisig=ACTRDVEAAAAAas-GVgi34VSVojs0nt7HO_YbU68&scisf=4&ct=citation&cd=-1&hl=en Nagel])
**The effect of anion-conducting channelrhodopsins (ACRs) on the activity of the neuron is comparable to GABAA receptors.
**'''Is the receptor, its components, or homologues of the gene expressed in different model organisms? What is the sequence similarity with human?'''
**'''Is the receptor, its components, or homologues of the gene expressed in different model organisms? What is the sequence similarity with human?'''
**'''Search [https://flybase.org flybase], [https://www.informatics.jax.org/ MGI], [https://www.wormbase.org/ wormbase], [https://zfin.org/ zebra fish information network], [https://www.yeastgenome.org/ yeast genome database]'''
**'''Search [https://flybase.org flybase], [https://www.informatics.jax.org/ MGI], [https://www.wormbase.org/ wormbase], [https://zfin.org/ zebra fish information network], [https://www.yeastgenome.org/ yeast genome database]'''