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→10/14 Summary
***Could we use optogenetics to clarify whether certain non-canonical propofol targets receptors (e.g. α4β2 nAChR, HCN1) are necessary or sufficient for its effects?
***Could we use optogenetics to clarify whether certain non-canonical propofol targets receptors (e.g. α4β2 nAChR, HCN1) are necessary or sufficient for its effects?
***Assuming that α1β2γ2 GABA<sub>A</sub>R is the critical receptor, can we demonstrate which circuits play a critical role?
***Assuming that α1β2γ2 GABA<sub>A</sub>R is the critical receptor, can we demonstrate which circuits play a critical role?
# Excitatory cortical pyramidal neurons
### Excitatory cortical pyramidal neurons
# Galan-/GABA-ergic POA-monoaminergic brainstem nuclei: LC (NE), DR (5HT), vPAG (DA), TMN (His)
### Galan-/GABA-ergic POA-monoaminergic brainstem nuclei: LC (NE), DR (5HT), vPAG (DA), TMN (His)
# GABAergic neurons in the TRN (thalamic reticular nucleus)
### GABAergic neurons in the TRN (thalamic reticular nucleus)
* Patch clamp
* Patch clamp
* Meeting with Hamilton
* Meeting with Hamilton