Changes

===Phylogenetic Approach===

===Phylogenetic Approach===

*Are there organisms that are resistant to anesthetics? Search for 'weird' organisms that might yield something interesting. Prokaryotes (bacteria, archaea) and Eukaryotes (Protists, Plants, Animals, Fungi). Single cellular and multicellular organisms. What is different about them?

*Are there organisms that are resistant to anesthetics? Search for 'weird' organisms that might yield something interesting. Prokaryotes (bacteria, archaea) and Eukaryotes (Protists, Plants, Animals, Fungi). Single cellular and Multicellular organisms. For resistant organisms, what is different about them?

**Downsides of using 'weird' organisms is that there are relatively few genetic tools, antibodies, sparse literature, and few experts to consult.

**Downsides of using 'weird' organisms is that there are relatively few genetic tools, antibodies, sparse literature, and few experts to consult.

**Has anyone published behavioral assays for these organisms? Detailed protocols for breeding them? Have they already been anesthetized?

**Has anyone published behavioral assays for these organisms? How do you make an argument that a slime mold has been anesthetized?

===Non Receptor-Mediated Hypothesis===

===Non Receptor-Mediated Hypothesis===