Changes

***Sacral

***Sacral

*'''PERIPHERAL'''

*'''PERIPHERAL'''

**'''Somatic''': ''corticospinal'' > ''anterior horns'' > ventral roots > skeletal muscles; peripheral sensory receptors > dorsal roots > ''DCML/spinothalamic''

**'''Somatic'''

**'''Autonomic''':

***Motor: ''primary motor cortex [[glutamatergic]] UMNs'' > ''corticospinal tract'' > ''anterior horn [[cholinergic]] alpha motor neurons (LMNs)'' > ventral roots > peripheral nerves > [[nAChRs]] on skeletal muscles

***Sympathetic: ''lateral horn'' > ventral roots > paravertebral sympathetic chain ganglia or prevertebral ganglia > target organs

***Sensory: peripheral sensory receptors > peripheral nerves > dorsal roots > ''DCML/spinothalamic''

**'''Autonomic'''

***Sympathetic: ''lateral horn [[cholinergic]] preganglionic neurons'' > ventral roots > white ramus communicans > paravertebral sympathetic chain or prevertebral ganglia > postganglionic [[noradrenergic]] neurons > gray ramus communicans > peripheral nerves > target organs

***Parasympathetic: craniosacral outflow from CN III/VII/IX/X and S2-S4 > peripheral ganglia near target organs > target organs

***Parasympathetic: craniosacral outflow from CN III/VII/IX/X and S2-S4 > peripheral ganglia near target organs > target organs

**'''Enteric'''

**'''Enteric'''