Difference between revisions of "Adrenergic Pharmacology"
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| Line 22: | Line 22: | ||
| | | | ||
*↑SVR, ↑MAP | *↑SVR, ↑MAP | ||
| − | * | + | *↓insulin release, ↓lipolysis, ↓aqueous humor production |
| | | | ||
| − | presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → | + | presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → ↓NT release, sympatholytic effects |
| | | | ||
*Dexmedetomidine | *Dexmedetomidine | ||
| Line 36: | Line 36: | ||
| β1 || Iso > NE > Epi | | β1 || Iso > NE > Epi | ||
| | | | ||
| − | *↑Chronotropy (myocytes), ↑Inotropy (SA node) | + | *↑Chronotropy (myocytes), ↑Inotropy (SA node), ↑SBP |
*↑Renin release/↑volume (JGA) | *↑Renin release/↑volume (JGA) | ||
*Amylase secretion | *Amylase secretion | ||
| Line 51: | Line 51: | ||
*Esmolol | *Esmolol | ||
|- | |- | ||
| − | | β2 || Iso > Epi > NE | | + | | β2 || Iso > Epi > NE |
| + | | | ||
| + | *Smooth muscle relaxation, ↓SVR, ↓DBP, ↓MAP | ||
| + | *Bronchodilation | ||
| + | *↑Lipolysis, ↑Insulin release | ||
| + | *Relax uterine smooth muscle | ||
| + | *↑aqueous humor production | ||
| + | | | ||
| + | G<sub>s</sub> → ↑cAMP → ↑PKA | ||
| | | | ||
*Albuterol | *Albuterol | ||
Revision as of 06:14, 4 February 2023
| Receptor | Binding Affinity | Effects | Mechanism | Agonists | Antagonists |
|---|---|---|---|---|---|
| α1 | NE > Epi >> Iso |
|
Gq → PLC → IP3/DAG → [Ca2+]i |
|
α1 selective:
|
| α2 | Epi = NE >> Iso |
|
presynaptic Gi → ↓AC → ↓cAMP → ↓NT release, sympatholytic effects |
|
Non-selective:
|
| β1 | Iso > NE > Epi |
|
Gs → ↑AC → ↑cAMP |
|
Cardiac Selective:
|
| β2 | Iso > Epi > NE |
|
Gs → ↑cAMP → ↑PKA |
|
Non-Selective:
|
| β3 | Iso > Epi = NE | Lipolysis, bladder detrusor relaxation | Gs, cAMP up |
|
|