1,415
edits
Changes
Jump to navigation
Jump to search
Line 37:
Line 37: + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
→November 11
* Read CLASS-D papers (1 hr)
* Read CLASS-D papers (1 hr)
* Open and briefly explore CLASS-D data (1 hr) -> 8 hrs total
* Open and briefly explore CLASS-D data (1 hr) -> 8 hrs total
==Ketamine Review==
{| class="wikitable"
|+ Caption text
|-
! Year !! First Author !! Journal !! Study Type !! Population !! Intervention !! Comparator !! Outcome
|-
| 2026 || He<ref>https://scholar.googleusercontent.com/scholar.bib?q=info:7qS3F--yeFIJ:scholar.google.com/&output=citation&scisdr=CoZuVH0GEIjgiyDP47s:AIL1Nv4AAAAAavTJ-7tyFiEi1Qu_9yh4Y6UEgLo&scisig=AIL1Nv4AAAAAavTJ-8Gwfmjrk5PwQo5j_k1Xif8&scisf=4&ct=citation&cd=-1&hl=en</ref> || J of Investigative Surgery || double-blind RCT || 132 adult patients undergoing lap radical resection for CRC || Intraoperative bolus at induction of 0.5 mg/kg ketamine plus an infusion of 1 mg/kg added to PCIA post-op || Placebo || Improved HADS-D on POD 1 and 3.
|-
| 2026 || Chen<ref>https://scholar.googleusercontent.com/scholar.bib?q=info:Z0jyPF9LhrQJ:scholar.google.com/&output=citation&scisdr=CoZuVH0GEIjgiyDMjfQ:AIL1Nv4AAAAAavTKlfQFArkJyVW4ef74Zs6FvOw&scisig=AIL1Nv4AAAAAavTKld7Rnl9NytXrtPhhYZwCiZo&scisf=4&ct=citation&cd=-1&hl=en</ref> || Annals of Medicine || double-blind RCT || 84 adult patients getting acoustic neuroma surgery || 0.2 mg/kg/hr continuous infusion of ketamine followed by 1 mg/kg PCIA post-op. || placebo || Esketamine significantly reduced the incidence of depression (HADS-D >7) at POD1 (7.7% versus 31.6%; relative risk 0.24, 95% CI: 0.08-0.80, p = 0.008) and POD3 (0.0% versus 15.8%, relative risk 0.00, 95% CI: 0.00-0.47, p = 0.031)
|-
| 2026 || Liu<ref>https://scholar.googleusercontent.com/scholar.bib?q=info:3s6CSOQL3SMJ:scholar.google.com/&output=citation&scisdr=CoZuVH0GEIjgiyDNCVA:AIL1Nv4AAAAAavTLEVDx8d26l8RmdQYOZ4DQjDs&scisig=AIL1Nv4AAAAAavTLEesuSPiaLgBcLmj2qnd2d1A&scisf=4&ct=citation&cd=-1&hl=en</ref> || BMC Psychiatry || double-blind RCT || 120 adult patients scheduled for breast cancer surgery || 0.2 mg/kg at induction, followed by a continuous infusion of 0.1 mg/kg/hr || placebo || At POD30, the ketamine group achieved a significantly greater reduction in PHQ-9 scores compared to the control group, with an adjusted mean difference of 0.96 points (95% CI 0.42-1.51, P < 0.01)
|-
| 2026 || Tan<ref>https://scholar.googleusercontent.com/scholar.bib?q=info:z9BP0cZwPRsJ:scholar.google.com/&output=citation&scisdr=CoZuVH0GEIjgiyDNmfo:AIL1Nv4AAAAAavTLgfrycb2mADviVzu-EWrvFeo&scisig=AIL1Nv4AAAAAavTLgdl5KWI3gXgLYzOqVDeedSw&scisf=4&ct=citation&cd=-1&hl=en</ref> || BMC Anesthesiology || RCT || 53 adult patients with PD || 0.25 mg/kg ketamine at induction followed by 0.125 mg/kg/hr continuous infusion || placebo || SDS scores at POD 1, 3, and 7 were lower in the ketamine group.
|-
| 2025 || He<ref>https://scholar.googleusercontent.com/scholar.bib?q=info:vBqsVnBf8b0J:scholar.google.com/&output=citation&scisdr=CoZuVH0GEIjgiyDN5mk:AIL1Nv4AAAAAavTL_mmlQrmOOlg5-9TZ5DE_CoM&scisig=AIL1Nv4AAAAAavTL_nMF6lRqFz3eARfm9LHiYYQ&scisf=4&ct=citation&cd=-1&hl=en</ref> || Psycho-Oncology || RCT || 230 adult patients with mild-to-moderate depressive symptoms undergoing abdominal tumor resection || 0.4 mg/kg ketamine at induction || placebo || On POD1 the ketamine group had a slightly higher treatment response (OR 1.4), and a mean decrease in PHQ-9 of 1, but it was not sustained at day 3 or 7.
|-
| 2025 || Zhang<ref>https://scholar.googleusercontent.com/scholar.bib?q=info:zMc0lUuZvr8J:scholar.google.com/&output=citation&scisdr=CoZuVH0GEIjgiyDKcyo:AIL1Nv4AAAAAavTMaypzfaFPiqjGh6Ilu5BmmIs&scisig=AIL1Nv4AAAAAavTMa-ZfpuJUpbWVrKvrh2teIc4&scisf=4&ct=citation&cd=-1&hl=en</ref> || Pharmacological Research || multi-center, double-blind RCT || 132 cardiac valve surgery patients || 0.3 mg/kg single dose ketamine at induction || placebo || HADS scores were significantly lower at POD7 in the ketamine group with rates of depression of 7% vs 31% in placebo.
|-
| 2025 || Luo<ref>https://scholar.googleusercontent.com/scholar.bib?q=info:ojpnDyfjUGMJ:scholar.google.com/&output=citation&scisdr=CoZuVH0GEIjgiyDIWd4:AIL1Nv4AAAAAavTOQd7afHEnxuJ-ehyTePuUWGo&scisig=AIL1Nv4AAAAAavTOQSLKahBZX979AB-jvMWeDkk&scisf=4&ct=citation&cd=-1&hl=en</ref> || Actas Espanolas de Psiquiatria || RCT || 280 patients who underwent elective caesarean section under spinal anaesthesia || single intravenous injection of esketamine at a dose of 0.25 mg/kg (diluted to 5 mL and administered intravenously within 10 min after foetus removal) || placebo || Primary outcome was EPDS score on PPD3. The patients with an extroverted-stable personality in the esketamine group had a lower PPD incidence than those in the control group (11.90% vs. 25.70%, p < 0.05). No statistical difference in overall PPD incidence was observed between the two groups (35.7% vs. 29.3%, p > 0.05), suggesting a possible treatment modifying effect of personality type.
|-
| 2025 || Wang<ref>https://scholar.googleusercontent.com/scholar.bib?q=info:FOb98jzqXU0J:scholar.google.com/&output=citation&scisdr=CoZuVH0GEIjgiyDX1M8:AIL1Nv4AAAAAavTRzM85cuA_p5XiofsUNAEsSQs&scisig=AIL1Nv4AAAAAavTRzL74T6uGJ2c_GQAEgLMI5jY&scisf=4&ct=citation&cd=-1&hl=en</ref> || BMC Geriatrics || double-blind RCT || 200 patients undergoing laparoscopic abdominal surgery aged 60 years or older || 0.3 mg/kg/h starting 10 min before the induction of anesthesia and continuing until the end of the surgical procedure || placebo || HADS-D score was significantly lower on POD1 and 3 (visually estimated from figure to be 10 vs. 11 and 7 vs 8 respectively).
|-
| Example || Example || Example || Example || Example || Example || Example || Example
|-
| Example || Example || Example || Example || Example || Example || Example || Example
|-
| Example || Example || Example || Example || Example || Example || Example || Example
|-
| Example || Example || Example || Example || Example || Example || Example || Example
|}