Changes

Search Strategy:

Last Updated 7/16/24. Ovid Medline Search Strategy:

--------------------------------------------------------------------------------

--------------------------------------------------------------------------------

1    Xenon/ (4750)

1    Xenon/ (4750)

   2012

   2012

'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med9&DO=10.1016%2fj.neuroscience.2012.03.063 Xenon-induced inhibition of synchronized bursts in a rat cortical neuronal network.]'''

 

  Xenon-induced inhibition of synchronized bursts in a rat cortical neuronal network.

Source

Source

   Neuroscience. 214:149-58, 2012 Jul 12.

   Neuroscience. 214:149-58, 2012 Jul 12.

 

Authors

Authors

   Uchida T; Suzuki S; Hirano Y; Ito D; Nagayama M; Gohara K

   Uchida T; Suzuki S; Hirano Y; Ito D; Nagayama M; Gohara K

 

Abstract

Abstract

   Xenon (Xe) and other inert gases produce anesthesia via an inhibitory mechanism in neuronal networks. To better understand this mechanism, we measured the electrical signals from cultured rat cortical neuronal networks in a multi-electrode array (MEA) under an applied Xe pressure. We used the MEA to measure the firing of the neuronal network with and without Xe gas pressurized to 0.3MPa. The MEA system monitored neuronal spikes on 16 electrodes (each 50x50mum(2)) at a sampling rate of 20kHz. The embryo rat cortical cells were first cultured on MEAs without Xe for approximately 3weeks, at which time they produced synchronized bursts that indicate maturity. Then, with an applied Xe pressure, the synchronized bursts quickly ceased, whereas single spikes continued. The Xe-induced inhibition-recovery of neuronal network firing was reversible: after purging Xe from the system, the synchronized bursts gradually resumed. Thus, Xe did not inhibit single neuron firing, yet reversibly inhibited the synaptic transmission. This finding agrees with the channel-blocker and a modified-hydrate hypothesis of anesthesia, but not the lipid-solubility hypothesis. Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

   Xenon (Xe) and other inert gases produce anesthesia via an inhibitory mechanism in neuronal networks. To better understand this mechanism, we measured the electrical signals from cultured rat cortical neuronal networks in a multi-electrode array (MEA) under an applied Xe pressure. We used the MEA to measure the firing of the neuronal network with and without Xe gas pressurized to 0.3MPa. The MEA system monitored neuronal spikes on 16 electrodes (each 50x50mum(2)) at a sampling rate of 20kHz. The embryo rat cortical cells were first cultured on MEAs without Xe for approximately 3weeks, at which time they produced synchronized bursts that indicate maturity. Then, with an applied Xe pressure, the synchronized bursts quickly ceased, whereas single spikes continued. The Xe-induced inhibition-recovery of neuronal network firing was reversible: after purging Xe from the system, the synchronized bursts gradually resumed. Thus, Xe did not inhibit single neuron firing, yet reversibly inhibited the synaptic transmission. This finding agrees with the channel-blocker and a modified-hydrate hypothesis of anesthesia, but not the lipid-solubility hypothesis. Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

Publication Type

Publication Type

   Journal Article. Research Support, Non-U.S. Gov't.

   Journal Article. Research Support, Non-U.S. Gov't.

Year of Publication

Year of Publication

   2012

   2012

<10>

 

'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&DO=10.1213%2fANE.0b013e3181be0e17 Closed-circuit xenon delivery using a standard anesthesia workstation.]'''

 

  Closed-circuit xenon delivery using a standard anesthesia workstation.

Source

Source

   Anesthesia & Analgesia. 110(1):101-9, 2010 Jan 01.

   Anesthesia & Analgesia. 110(1):101-9, 2010 Jan 01.

 

Authors

Authors

   Rawat S; Dingley J

   Rawat S; Dingley J

 

Abstract

Abstract

   BACKGROUND: Xenon (Xe) is an anesthetic with minimal side effects, now also showing promise as a neuroprotectant both in vitro and in vivo. Although scarce and expensive, Xe is insoluble and patient uptake is low, making closed circuits the optimum delivery method. Although the future of Xe anesthesia is uncertain, effective neuroprotection is highly desirable even if moderately expensive. A factor limiting Xe research in all these fields may be the perceived need to purchase special Xe anesthesia workstations that are expensive and difficult to service. We investigated the practicality of 1) true closed-circuit Xe delivery using an unmodified anesthesia workstation with gas monitoring/delivery attachments restricted to breathing hoses only, 2) a Xe delivery protocol designed to eliminate wastage, and 3) recovering Xe from exhaled gas.

   BACKGROUND: Xenon (Xe) is an anesthetic with minimal side effects, now also showing promise as a neuroprotectant both in vitro and in vivo. Although scarce and expensive, Xe is insoluble and patient uptake is low, making closed circuits the optimum delivery method. Although the future of Xe anesthesia is uncertain, effective neuroprotection is highly desirable even if moderately expensive. A factor limiting Xe research in all these fields may be the perceived need to purchase special Xe anesthesia workstations that are expensive and difficult to service. We investigated the practicality of 1) true closed-circuit Xe delivery using an unmodified anesthesia workstation with gas monitoring/delivery attachments restricted to breathing hoses only, 2) a Xe delivery protocol designed to eliminate wastage, and 3) recovering Xe from exhaled gas.

   CONCLUSIONS: We report that closed-circuit Xe delivery can be achieved with a modified standard anesthesia workstation with breathing hose alterations only and that the protocol was very gas efficient, especially during the normally wasteful Xe wash-in. A Xe mixture of > or = 50% was delivered for up to 341 min (5 h 41 min) and Xe consumption was 4.95 (0.82) L/h, maintenance being achieved with 2-3 L/h. With this degree of efficiency, Xe recovery/recycling at the end of anesthesia may be of little additional benefit.

   CONCLUSIONS: We report that closed-circuit Xe delivery can be achieved with a modified standard anesthesia workstation with breathing hose alterations only and that the protocol was very gas efficient, especially during the normally wasteful Xe wash-in. A Xe mixture of > or = 50% was delivered for up to 341 min (5 h 41 min) and Xe consumption was 4.95 (0.82) L/h, maintenance being achieved with 2-3 L/h. With this degree of efficiency, Xe recovery/recycling at the end of anesthesia may be of little additional benefit.

Publication Type

Publication Type

   Journal Article.

   Journal Article.

Year of Publication

Year of Publication

   2010

   2010

 

'''[ https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&DO=10.1213%2f01.ane.0000278148.56305.72 A cryogenic machine for selective recovery of xenon from breathing system waste gases.]'''

 

  A cryogenic machine for selective recovery of xenon from breathing system waste gases.

Source

Source

   Anesthesia & Analgesia. 105(5):1312-8, table of contents, 2007 Nov.

   Anesthesia & Analgesia. 105(5):1312-8, table of contents, 2007 Nov.

 

Authors

Authors

   Dingley J; Mason RS

   Dingley J; Mason RS

 

Abstract

Abstract

   BACKGROUND: Xenon has many characteristics that make it very attractive as an anesthetic and therapeutic drug. Unfortunately, the supply of xenon is fixed, and therefore reclamation and recovery from even the most efficient breathing circuits is desirable. We built and evaluated a cryogenic device to recover xenon from waste anesthetic gases.

   BACKGROUND: Xenon has many characteristics that make it very attractive as an anesthetic and therapeutic drug. Unfortunately, the supply of xenon is fixed, and therefore reclamation and recovery from even the most efficient breathing circuits is desirable. We built and evaluated a cryogenic device to recover xenon from waste anesthetic gases.

   CONCLUSIONS: Xenon of high purity (>90%) and yield (>70%) for such a machine was recovered from all gas mixtures containing > or =20% xenon. The operating temperature of the freezing chamber is a major influence on the efficiency of recovery.

   CONCLUSIONS: Xenon of high purity (>90%) and yield (>70%) for such a machine was recovered from all gas mixtures containing > or =20% xenon. The operating temperature of the freezing chamber is a major influence on the efficiency of recovery.

Publication Type

Publication Type

   Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.

   Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.

Year of Publication

Year of Publication

   2007

   2007

'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med1&DO=10.1007%2fBF02477814 A recovery system for hyperbaric xenon.]'''

 

  A recovery system for hyperbaric xenon.

Source

Source

   Medical & Biological Engineering. 12(3):386-8, 1974 May.

   Medical & Biological Engineering. 12(3):386-8, 1974 May.

 

Authors

Authors

   Porter AL

   Porter AL

 

Publication Type

Publication Type

   Journal Article.

   Journal Article.

Year of Publication

Year of Publication

   1974

   1974

'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med1&DO=10.1016%2f0020-708x%2871%2990146-3 Recovery of 133 Xe from the expired gas in lung function studies.]'''

 

  Recovery of 133 Xe from the expired gas in lung function studies.

Source

Source

   International Journal of Applied Radiation & Isotopes. 22(12):785-6, 1971 Dec.

   International Journal of Applied Radiation & Isotopes. 22(12):785-6, 1971 Dec.

 

Authors

Authors

   Vaalburg W; Peset R; Beekhus H; Woldring MG; Tammeling GJ

   Vaalburg W; Peset R; Beekhus H; Woldring MG; Tammeling GJ

 

Publication Type

Publication Type

   Journal Article.

   Journal Article.

Year of Publication

Year of Publication

   1971

   1971