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Line 134: − ***GABA is also an important neurotransmitter in [https://www.ncbi.nlm.nih.gov/books/NBK19793/ C. elegans]; however, in contrast to vertebrates where GABA acts at synapses of the central nervous system, in nematodes GABA acts primarily at neuromuscular synapses. Specifically, GABA acts to relax the body muscles during locomotion and foraging and to contract the enteric muscles during defecation.+
→Genetic Probing of Anesthetic-Receptor Interactions
* ''C. elegans'' don't have any histamine signaling natively. You can make animals that express histamine-gated chloride channels to chemogenetically inactivate channel expressing neurons when histamine is given exogenously. '''Look for a GABA<sub>A</sub>R His-Cl worm line.
* ''C. elegans'' don't have any histamine signaling natively. You can make animals that express histamine-gated chloride channels to chemogenetically inactivate channel expressing neurons when histamine is given exogenously. '''Look for a GABA<sub>A</sub>R His-Cl worm line.
** He is going to send me some links to worm genetic databases, and some protocols for breeding and behavior.
** He is going to send me some links to worm genetic databases, and some protocols for breeding and behavior.
**GABA is also an important neurotransmitter in [https://www.ncbi.nlm.nih.gov/books/NBK19793/ C. elegans]; however, in contrast to vertebrates where GABA acts at synapses of the central nervous system, in nematodes GABA acts primarily at neuromuscular synapses. Specifically, GABA acts to relax the body muscles during locomotion and foraging and to contract the enteric muscles during defecation.
===EEG Approach===
===EEG Approach===