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*Feasibile and high-impact research ideas:
*Feasibile and high-impact research ideas:
**Depression
**Depression
***What is the disease burden of depression in the general surgical population? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c14%7c1&Counter5=SS_view_found_complete%7c40404498%7cmedall%7cmedline%7cmed29&Counter5Data=40404498%7cmedall%7cmedline%7cmed29 BJA article] that finds 20% burden of depression in the surgical patients during the pre-op period. They also note that patients have a 2.5x higher risk of non-home discharge. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c16%7c1&Counter5=SS_view_found_complete%7c41495495%7cmedall%7cmedline%7cmed29&Counter5Data=41495495%7cmedall%7cmedline%7cmed29 2026 systematic review and meta-analysis] showing that about 1/4 of surgical cancer patients have depression.
***What is the disease burden of depression in the general surgical population? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c14%7c1&Counter5=SS_view_found_complete%7c40404498%7cmedall%7cmedline%7cmed29&Counter5Data=40404498%7cmedall%7cmedline%7cmed29 BJA article] that finds 20% burden of depression in the surgical patients during the pre-op period. They also note that patients have a 2.5x higher risk of non-home discharge. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c16%7c1&Counter5=SS_view_found_complete%7c41495495%7cmedall%7cmedline%7cmed29&Counter5Data=41495495%7cmedall%7cmedline%7cmed29 2026 systematic review and meta-analysis] showing that about 1/4 of surgical cancer patients have depression. [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c19%7c1&Counter5=SS_view_found_complete%7c41337802%7cmedall%7cmedline%7cmed29&Counter5Data=41337802%7cmedall%7cmedline%7cmed29 2026 Journal of Clinical Neuroscience] article showed a 4-fold increase in risk of re-operation in ACDF patients who were depressed.
***What is the incidence of post-operative depression in general surgical patients without pre-existing depression? What if they have a family or personal history of depression?
***What is the incidence of post-operative depression in general surgical patients without pre-existing depression? What if they have a family or personal history of depression?
***Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c2%7c1&Counter5=SS_view_found_complete%7c42657795%7cmedall%7cmedline%7cmedl&Counter5Data=42657795%7cmedall%7cmedline%7cmedl RCT happening in China right now]
***Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk? [https://ovidsp.dc2.ovid.com/ovid-new-a/ovidweb.cgi?&S=20719da3-5171-468d-a340-25cdcf20c6e6%7cmain&Complete+Reference=S.sh.50%7c2%7c1&Counter5=SS_view_found_complete%7c42657795%7cmedall%7cmedline%7cmedl&Counter5Data=42657795%7cmedall%7cmedline%7cmedl RCT happening in China right now]