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[https://journals-lww-com.ezproxy.lib.utah.edu/anesthesiology/pdf/10.1097/00000542-198212000-00005~pharmacodynamics-and-pharmacokinetics-of-methadone-during A 1982 study] published in Anesthesiology reported that 23 general surgery and orthopedic patients were given 20 mg IV methadone bolus at induction, 100% required no additional opioids in the first 18 hrs post-op. 25% required only non-opioid analgesics. 40% did not need any additional treatment for post-op pain. There was no respiratory depression.
[https://journals-lww-com.ezproxy.lib.utah.edu/anesthesiology/pdf/10.1097/00000542-198212000-00005~pharmacodynamics-and-pharmacokinetics-of-methadone-during A 1982 study] published in Anesthesiology reported that 23 general surgery and orthopedic patients were given 20 mg IV methadone bolus at induction, 100% required no additional opioids in the first 18 hrs post-op. 25% required only non-opioid analgesics. 40% did not need any additional treatment for post-op pain. There was no respiratory depression.
Ovid MEDLINE(R) ALL <1946 to September 23, 2026>
1 Methadone/ 14563
2 (nature or science or new england journal of medicine or british journal of anaesthesia or anaesthesia or anesthesiology or anesthesia & analgesia).jn. 520093
3 1 and 2 233
4 limit 3 to humans 198
5 limit 4 to "all adult (19 plus years)" 72
6 from 5 keep 1,3,6-9,11,13-14,16-17,22,25,28,30,44,47-49,51,58,66 22