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→Mechanisms of Anesthesia
**Dexmedetomidine binds to α<sub>2A</sub> AR w/ K<sub>D</sub> of 0.0014 uM and the M<sub>3</sub> mAChR w/ IC<sub>50</sub> of 0.001 uM.
**Dexmedetomidine binds to α<sub>2A</sub> AR w/ K<sub>D</sub> of 0.0014 uM and the M<sub>3</sub> mAChR w/ IC<sub>50</sub> of 0.001 uM.
**Etomidate binds to α1β2γ2 GABA<sub>A</sub>R w/ an EC<sub>50</sub> of 1.08 uM, but to I<sub>K(dr)</sub> with an IC<sub>50</sub> of 4.59 uM, and the α1 GlyR w/ an IC<sub>50</sub> of 5.37 uM.
**Etomidate binds to α1β2γ2 GABA<sub>A</sub>R w/ an EC<sub>50</sub> of 1.08 uM, but to I<sub>K(dr)</sub> with an IC<sub>50</sub> of 4.59 uM, and the α1 GlyR w/ an IC<sub>50</sub> of 5.37 uM.
**Midazolam binds to α1β2γ2 GABA<sub>A</sub>R w/ EC<sub>50</sub> of 0.041 uM, Na<sub>V</sub> (neuron) IC<sub>50</sub> of 0.074 uM, and nAChR (muscle) w/ IC<sub>50</sub> of 0.143 uM.
**Midazolam binds to α1β2γ2 GABA<sub>A</sub>R, between the α1 and γ2 subunits, w/ EC<sub>50</sub> of 0.041 uM, Na<sub>V</sub> (neuron) IC<sub>50</sub> of 0.074 uM, and nAChR (muscle) w/ IC<sub>50</sub> of 0.143 uM.
**Diazepam binds to '''α1β2γ2 GABA<sub>A</sub>R''' w/ EC<sub>50</sub> of 0.07 uM.
**Diazepam binds to '''α1β2γ2 GABA<sub>A</sub>R''' w/ EC<sub>50</sub> of 0.07 uM.
**Sevoflurane binds to '''K<sub>v</sub>1.2''' w/ EC<sub>50</sub> of 0.0097 mM.
**Sevoflurane binds to '''K<sub>v</sub>1.2''' w/ EC<sub>50</sub> of 0.0097 mM.
| α1β2γ2 GABA<sub>A</sub>R || flumazenil || protoporphyrin IX, α2,3,5, γ3 || yes || yes
| α1β2γ2 GABA<sub>A</sub>R || flumazenil || protoporphyrin IX, α2,3,5, γ3 || yes || yes
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| α1β2γ2 GABA<sub>A</sub>R || brexanolone || δ, γ3 || ??? || yes
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| α1β2γ2 GABA<sub>A</sub>R || example || example || example || example
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| HCN1 || Example || Example || Example || Example
| HCN1 || Example || Example || Example || Example
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