**This section should be focused and contain no more than 400 words. The Introduction succinctly describes, in a series of short paragraphs, the significance of the topic, pertinent background, rationale for the study, a priori study aims or objectives, and primary study hypothesis, and if appropriate, secondary study hypothesis. | **This section should be focused and contain no more than 400 words. The Introduction succinctly describes, in a series of short paragraphs, the significance of the topic, pertinent background, rationale for the study, a priori study aims or objectives, and primary study hypothesis, and if appropriate, secondary study hypothesis. |