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A small, single center, retrospective cohort study at a US hospital looked at patients with chronic pancreatitis who were treated with 1.) intrathecal morphine pump (n=13) or 2.) total pancreatectomy with autologous islet cell transplant (n=30). Both lead to clinically significant pain relief and decreased MME requirement in chronic pancreatitis. Surgical treatment, even with islet cell transplant, has increased risk of developing post-operative insulin-dependent diabetes (about 46% of patients at 5-year follow-up).

A small, single center, retrospective cohort study at a US hospital looked at patients with chronic pancreatitis who were treated with 1.) intrathecal morphine pump (n=13) or 2.) total pancreatectomy with autologous islet cell transplant (n=30). Both lead to clinically significant pain relief and a large decrease in MME. Surgical treatment, even with islet cell transplant, has increased risk of developing post-operative insulin-dependent diabetes (about 46% of patients at 5-year follow-up per a different study).