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Line 5: − ==DIAGNOSIS==+ − + − ¿Eyed frat' cuitisten a forfindsfficile. The best test performance characteristics+ − ===Diagnostic criteria=== − + − ===Diagnostic approaches===+ Line 31:
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→DIAGNOSIS
Systematic review of 116 included studies between 1978 and 2014.
Systematic review of 116 included studies between 1978 and 2014.
=DIAGNOSIS=
* Laboratory testing cannot distinguish between asymptomatic colonization and
* Laboratory testing cannot distinguish between asymptomatic colonization and active infection.
==Diagnostic criteria==
* Diarrhea
* Diarrhea
* Positive stool test for toxigenic C. diff or toxins or pseudomembranous colitis
* Positive stool test for toxigenic C. diff or toxins or visualization of pseudomembranous colitis
==Diagnostic approaches==
* Toxigenic Culture (TC) and/or Cell Cytotoxicity Assay (CCA)
* Toxigenic Culture (TC) and/or Cell Cytotoxicity Assay (CCA)
** Anaerobic culture for 24-48 hrs followed by colony selection and culture with human cells to test for cell cytotoxicity which takes an additional 24-48 hours.
** Anaerobic culture for 24-48 hrs followed by colony selection and culture with human cells to test for cell cytotoxicity which takes an additional 24-48 hours.
* Both positive = C. diff
* Both positive = C. diff
* Both negative = NO C. diff
* Both negative = NO C. diff
* Mixed results, use PCR for tedB as tiebreaker
* Mixed results, use PCR for tcdB as tiebreaker
** Toxin EIA 1 (Meridian), higher PPV, lower NPV
** Toxin EIA 1 (Meridian), higher PPV, lower NPV
** Toxin EIA 2 (TechLab), lower PPV, higher NPV
** Toxin EIA 2 (TechLab), lower PPV, higher NPV