Changes

===CLAN===

===CLAN===

*Definitely want to continue the alpha entrainment analgesia study.

====Alpha entrainment analgesia study====

**Successfully entrain alpha. What were we doing wrong? '''Is there anything in the literature that can guide a protocol modification?'''

**Successfully entrain alpha. What were we doing wrong? '''Is there anything in the literature that can guide a protocol modification?'''

**Can I incorporate withdrawal thresholds?

**Can I incorporate withdrawal thresholds?

**Power analysis based on pilot study

**Power analysis based on pilot study

**'''Systematic review and meta analysis'''

**'''Systematic review and meta analysis'''

*What are the EEG effects of benzos, opioids, precedex, and their respective reversal agents, caffeine, methylphenidate, and methohexital? In MedLine, combine each agent with the search term electroencephalography and add limits for Adults, Humans, and English. Which drugs are most target selective? What are their EEG effects?

====EEG effects of anesthetic agents====

**Yohimbine = 9

Benzos, opioids, precedex, and their respective reversal agents, caffeine, methylphenidate, and methohexital? In MedLine, combine each agent with the search term electroencephalography and add limits for Adults, Humans, and English. Which drugs are most target selective? What are their EEG effects?

***Yohimbine stimulates NE release from the locus ceruleus (riba2005journalofneuroscience). It decreases latency of the P200 in ERPs, suggesting a possible improvement in selective attention to environmental stimuli (turetsky2002psychophysiology).

*Yohimbine = 9

**Naloxone = 28

**Yohimbine stimulates NE release from the locus ceruleus (riba2005journalofneuroscience). It decreases latency of the P200 in ERPs, suggesting a possible improvement in selective attention to environmental stimuli (turetsky2002psychophysiology).

***Fentanyl self-administration and passive administration (1.5 mg/70 kg) have differential [https://scholar.googleusercontent.com/scholar.bib?q=info:Ct07MzeWBcsJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixEInRc:ACTRDVEAAAAAasUOhRdfe7UiiUuK6P0C3uTTzcQ&scisig=ACTRDVEAAAAAasUOhZZOppryrz-KHD6fwDheYes&scisf=4&ct=citation&cd=-1&hl=en EEG effects], including higher central-midline delta enhancement.

*Naloxone = 28

**Methylphenidate = 68

**Fentanyl self-administration and passive administration (1.5 mg/70 kg) have differential [https://scholar.googleusercontent.com/scholar.bib?q=info:Ct07MzeWBcsJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixEInRc:ACTRDVEAAAAAasUOhRdfe7UiiUuK6P0C3uTTzcQ&scisig=ACTRDVEAAAAAasUOhZZOppryrz-KHD6fwDheYes&scisf=4&ct=citation&cd=-1&hl=en EEG effects], including higher central-midline delta enhancement.

**Methohexital = 80

*Methylphenidate = 68

**Flumazenil = 94

*Methohexital = 80

**Caffeine = 138

*Flumazenil = 94

*Caffeine = 138

===CO2===

===CO2===