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→Mechanisms of Anesthesia
**Sevoflurane binds to '''K<sub>v</sub>1.2''' w/ EC<sub>50</sub> of 0.0097 mM.
**Sevoflurane binds to '''K<sub>v</sub>1.2''' w/ EC<sub>50</sub> of 0.0097 mM.
*'''Are there pharmacological agents with effects opposite of anesthetics and with receptor specificity? Do they cross the blood brain barrier? Search [https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL63354/ ChEMBL]. When given together with "promiscuous" anesthetics, what happens? For instance, is propofol equally effective when given with a specific HCN1 receptor inhibitor? What about a GABA<sub>A</sub>R inhibitor?'''
*'''Are there pharmacological agents with effects opposite of anesthetics and with receptor specificity? Do they cross the blood brain barrier? Search [https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL63354/ ChEMBL].'''
{| class="wikitable sortable"
{| class="wikitable sortable"
|+ Caption text
|+ Caption text
| K<sub>v</sub>1.2 || Example || Example || Example || Example
| K<sub>v</sub>1.2 || Example || Example || Example || Example
|}
|}
*'''When given together with "promiscuous" anesthetics, what happens? For instance, is propofol equally effective when given with a specific HCN1 receptor inhibitor? What about a GABA<sub>A</sub>R inhibitor?'''
*'''Are there genetic KO/KD or optogenetic tools available for location-specific inducible receptor knockdowns?'''
*'''Are there genetic KO/KD or optogenetic tools available for location-specific inducible receptor knockdowns?'''
**'''Is the receptor, its components, or homologues of the gene expressed in different model organisms? What is the sequence similarity with human?'''
**'''Is the receptor, its components, or homologues of the gene expressed in different model organisms? What is the sequence similarity with human?'''