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| | *Lab meeting w/ Christian | | *Lab meeting w/ Christian |
| | *Accepted invite to teach EEG workshop at February meeting | | *Accepted invite to teach EEG workshop at February meeting |
| − | *IARS abstract submission deadline is 12/6 | + | *IARS abstract submission deadline is 12/6 (methohexital, flumazenil/propofol patch clamp, SCD-PV) |
| | | | |
| | ==Mechanisms of Anesthesia== | | ==Mechanisms of Anesthesia== |
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| | *'''When given together with "promiscuous" anesthetics, what happens? For instance, is propofol equally effective when given with a specific HCN1 receptor inhibitor? What about a GABA<sub>A</sub>R inhibitor?''' | | *'''When given together with "promiscuous" anesthetics, what happens? For instance, is propofol equally effective when given with a specific HCN1 receptor inhibitor? What about a GABA<sub>A</sub>R inhibitor?''' |
| | *'''Are there genetic KO/KD or optogenetic tools available for location-specific inducible receptor knockdowns?''' | | *'''Are there genetic KO/KD or optogenetic tools available for location-specific inducible receptor knockdowns?''' |
| | + | **Optogenetics has been used to inhibit neurons ([https://scholar.googleusercontent.com/scholar.bib?q=info:E5ci0TmjTyUJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuAMnI:ACTRDVEAAAAAas-GKnJgn-bjNlsNLChcKv4my2s&scisig=ACTRDVEAAAAAas-GKgEqKyhrCyTgoY7wITcfbIk&scisf=4&ct=citation&cd=-1&hl=en Boyden] [https://scholar.googleusercontent.com/scholar.bib?q=info:5bB4NZj9XJwJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuAD4Q:ACTRDVEAAAAAas-GF4QQx1MktzR7KJjHy7lxqtc&scisig=ACTRDVEAAAAAas-GF0WwYhYzurZCN_BZ43PKYBA&scisf=4&ct=citation&cd=-1&hl=en Zhang]) and control motor responses in ''C. elegans'' ([https://scholar.googleusercontent.com/scholar.bib?q=info:DR_TtH156CwJ:scholar.google.com/&output=citation&scisdr=CiBKb9IEEIjgixuATj4:ACTRDVEAAAAAas-GVj4eXZwSNxuPraJTtvvWPi4&scisig=ACTRDVEAAAAAas-GVgi34VSVojs0nt7HO_YbU68&scisf=4&ct=citation&cd=-1&hl=en Nagel]) |
| | **'''Is the receptor, its components, or homologues of the gene expressed in different model organisms? What is the sequence similarity with human?''' | | **'''Is the receptor, its components, or homologues of the gene expressed in different model organisms? What is the sequence similarity with human?''' |
| | **'''Search [https://flybase.org flybase], [https://www.informatics.jax.org/ MGI], [https://www.wormbase.org/ wormbase], [https://zfin.org/ zebra fish information network], [https://www.yeastgenome.org/ yeast genome database]''' | | **'''Search [https://flybase.org flybase], [https://www.informatics.jax.org/ MGI], [https://www.wormbase.org/ wormbase], [https://zfin.org/ zebra fish information network], [https://www.yeastgenome.org/ yeast genome database]''' |