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→10/14 Summary
*Accepted invite to teach EEG workshop at February meeting (coordinate with Christian who does what)
*Accepted invite to teach EEG workshop at February meeting (coordinate with Christian who does what)
*IARS abstract submission deadline is 12/6 (methohexital, flumazenil/propofol patch clamp, SCD-PV)
*IARS abstract submission deadline is 12/6 (methohexital, flumazenil/propofol patch clamp, SCD-PV)
*Reach out to Grace about ketamine research brainstorm.
*Thinking about propofol mechanisms
**Read all about GABA receptors in Principles of Neural Science
* Optogenetics can control the activity of a genetically defined set of neurons to see if they are important for your topic of interest. e.g. express Anion-conducting channelrhodopsins (ACRs, an inhibitory type of ChR) in α1β2γ2 GABA-R expressing neurons.
**Could we use optogenetics to clarify whether certain non-canonical propofol targets receptors (e.g. α4β2 nAChR, HCN1) are necessary or sufficient for its effects?
**Assuming that α1β2γ2 GABA<sub>A</sub>R is the critical receptor, can we demonstrate which circuits play a critical role?
# Excitatory cortical pyramidal neurons
# Galan-/GABA-ergic POA-monoaminergic brainstem nuclei: LC (NE), DR (5HT), vPAG (DA), TMN (His)
# GABAergic neurons in the TRN (thalamic reticular nucleus)
* Patch clamp
* Meeting with Hamilton
Lab meeting
IARS
* SCD PV
* Methohexital
==Mechanisms of Anesthesia==
==Mechanisms of Anesthesia==