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October 2026
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***Assuming that α1β2γ2 GABA<sub>A</sub>R is the critical receptor, can we demonstrate which circuits play a critical role?
***Assuming that α1β2γ2 GABA<sub>A</sub>R is the critical receptor, can we demonstrate which circuits play a critical role?
## Excitatory cortical pyramidal neurons
## Excitatory cortical pyramidal neurons
−
## Galan-/GABA-ergic POA
-
monoaminergic brainstem nuclei: LC (NE), DR (5HT), vPAG (DA), TMN (His)
+
## Galan-/GABA-ergic
hypothalamic
POA
projections to
monoaminergic brainstem nuclei: LC (NE), DR (5HT), vPAG (DA), TMN (His)
## GABAergic neurons in the TRN (thalamic reticular nucleus)
## GABAergic neurons in the TRN (thalamic reticular nucleus)
* Patch clamp
* Patch clamp
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