1,383
edits
Changes
Jump to navigation
Jump to search
Line 37:
Line 37: − + Line 152:
Line 152: − + − + Line 162:
Line 162: − + − +
→Heterodox Hypothesis
*Attended SandLab meeting.
*Attended SandLab meeting.
*Called Christian (consistently has Wed/Thu off, added me to two IRB protocols after I uploaded CITI competency to ERICA system)
*Called Christian (consistently has Wed/Thu off, added me to two IRB protocols after I uploaded CITI competency to ERICA system)
*COMPASS protocol we do need to consent patients (what is it?)
*COMPASS protocol we do need to consent patients
*Cameron Jacobson added access to local SAND lab web disk.
*Cameron Jacobson added access to local SAND lab web disk.
*GitHub can pull functions to work on data from the web disk. Srdjan added me to the main branch.
*GitHub can pull functions to work on data from the web disk. Srdjan added me to the main branch.
===EEG Approach===
===EEG Approach===
*Emergence from different anesthetics in patients with SEEG implants. Can we correlate this with fMRI and scalp EEG or eCOG?
*Can we correlate DECODE data with fMRI or eCOG?
*'''Is emergence just induction backwards? If not, what can that tell you about mechanisms?'''
*Emergence is not just induction backwards. There's neural inertia and hysteresis. What can this tell you about mechanisms of different agents?
===Phylogenetic Approach===
===Phylogenetic Approach===
===Heterodox Hypothesis===
===Heterodox Hypothesis===
*If you can anesthetize single-celled organisms, are circuits irrelevant?
*If you can anesthetize single-celled organisms, are circuits irrelevant?
*Hamilton has a gap junction (network of gap junctions?) and some specific neurons that he think are a conserved mechanism of anesthesia. He wants to test this by doing a screen of a bunch of different anesthetics in WT and KO worms with a behavioral screening assay. He has a behavior rig that basically automatically records swimming speed. He wants to look for the EC50 of various anesthetics and see if that number is shifted with KO or KD of different gap junctions.
*Hamilton has a gap junction (network of gap junctions?) and some specific neurons that he think are a conserved mechanism of anesthesia. He wants to test this by doing a screen of a bunch of different anesthetics in WT and KO worms with a behavioral screening assay. He wants to look for the EC50 of various anesthetics and see if that number is shifted with KO or KD of different gap junctions.
*Worms natively have a blue-light rhodopsin that triggers an aversion response where they turn around and go the opposite direction.
*Worms natively have a blue-light rhodopsin that triggers an aversion response where they turn around and go the opposite direction.
*I am going to '''read up on propofol mechanisms in worms, and gap junctions''' before our next meeting on 10/29.
*'''Read up on gap junctions'''.
==DECODE==
==DECODE==