− | *Dx: Differentiate from MCI (which has less severe symptoms that do not interfere with ADLs). Differential includes [[Alzheimer disease]] (most common), Parkinson disease, Lewy body dementia, '''frontotemporal dementia (Pick disease)''', vascular dementia, and [[Creutzfeld Jacob disease]] (prions). Check for '''reversible causes''' (TSH, B12, B6, urine tox screen, EtOH levels, infectious workups, depression screen). | + | *Dx: Differentiate from MCI (which has less severe symptoms that do not interfere with ADLs). Differential includes [[Alzheimer disease]] (most common), Parkinson disease, Lewy body dementia, '''frontotemporal dementia (Pick disease, 20% of patients can have UMN/LMN disease)''', vascular dementia, and [[Creutzfeld Jacob disease]] (prions, myoclonus, rapidly progressive, mutism). Check for '''reversible causes''' (TSH, B12, B6, urine tox screen, EtOH levels, infectious workups, depression screen). |
| *Tx: Based on etiology. '''AChE inhibitors: donepezil, <u>rivastigmine</u>, galantamine.''' Memantine ('''NMDA antagonist'''). Assisted living and social support. | | *Tx: Based on etiology. '''AChE inhibitors: donepezil, <u>rivastigmine</u>, galantamine.''' Memantine ('''NMDA antagonist'''). Assisted living and social support. |