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→PBC
==PBC==
==PBC==
*H&P: Age 30-65; F>M; Fatigue and jaundice; pruritis and osteoporosis; associated with hypothyroid and arthritis
*H&P: Age 30-65; F>M; Fatigue and jaundice; pruritis and osteoporosis; associated with hypothyroid and arthritis
*Dx: Positive AMA, elevated ALK, mildly elevated AST and ALT
*Dx: Elevated ALK + bili, positive AMA
*Tx: Ursodeoxycholic acid, cholestyramine, fat-soluble vitamins; transplant in rare cases
*Tx: Ursodeoxycholic acid, cholestyramine, fat-soluble vitamins; transplant in rare cases