Changes

! Opioid !! Dose !! Onset !! Duration !! Elimination !! Unique effects/indications

! Opioid !! Dose !! Onset !! Duration !! Elimination !! Unique effects/indications

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| Fentanyl || 1-20 ug/kg || 4-6 min || 15-30 min || Hepatic/Renal || Example

| Fentanyl || 1-20 ug/kg || 4-6 min || 30-45 min || Hepatic || Not used as infusion

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| Sufentanyl || 0.3-1 ug/kg || 2-4 min || 5-15 min || Hepatic/Renal || Example

| Sufentanyl || 0.3-1 ug/kg || 1-2 min || 20-40 min || Hepatic || ...

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| Remifentanyl || 0.1-0.3 ug/kg || 1-2 min || 2-5 min || Plasma esterases || Example

| Remifentanyl || 0.3-1 ug/kg || 1-1.5 min || 5-10 min || Plasma esterases, context sensitive half-life || Profound hypotension/bradycardia, "MAC sparing" reduces need for other anesthetics by 75%

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| Alfentanyl || 15-50 ug/kg || Example || Example || Hepatic/Renal || Example

| Alfentanyl || 5-50 ug/kg || 1-2 min || 20 min || Hepatic || ...

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| Morphine sulfate || 25-75 mg || 10-30 min || 2-5 hrs || Example || Can cause histamine release

| Morphine sulfate || 25-75 mg || 10-30 min || 2-5 hrs || Hepatic || Can cause histamine release

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| Meperidine || Example || 10-30 min || 2-5 hrs || Example || Used for post-op shivering

| Meperidine || Example || 10-30 min || 2-5 hrs || Hepatic || Used for post-op shivering, can't give to patients taking MAOIs

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