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* Don’t combine [[benzodiazepines]] and opioids. If you need to reverse, use [[flumazenil]].
* Don’t combine [[benzodiazepines]] and opioids. If you need to reverse, use [[flumazenil]].
* Central loci of opioid action (descending inhibitory pain pathways)
** PAG
** Nucleus Raphe magnus
** Rostral ventromedial medulla
=Short-Acting=
=Short-Acting=
* Oxycodone, Hydromorphone, Morphine
* Oxycodone, Hydromorphone, Morphine