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'''Top-Line Summary:'''

Intrathecal morphine pump and total pancreatectomy with autologous islet cell transplant both lead to clinically significant pain relief and decreased MME requirement in chronic pancreatitis. Surgical treatment, even with islet cell transplant, has increased risk of developing post-operative insulin-dependent diabetes.

A small, single center, retrospective cohort study at a US hospital looked at patients with chronic pancreatitis who were treated with 1.) intrathecal morphine pump (n=13) or 2.) total pancreatectomy with autologous islet cell transplant (n=30). Both lead to clinically significant pain relief and decreased MME requirement in chronic pancreatitis. Surgical treatment, even with islet cell transplant, has increased risk of developing post-operative insulin-dependent diabetes (about 46% of patients at 5-year follow-up).