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Line 2: − + − 3 harvesting.mp. (54413)+ − 4 recapture.mp. (5204)+ − 5 capture.mp. (172877)+ − 6 recovery.mp. (624609)+ − 7 2 or 3 or 4 or 5 or 6 (851731) − 8 1 and 7 (119) − 9 from 8 keep 15,17-19,21,37-38,51,57,111,115 (13) − + Line 27:
Line 24: − Year of Publication − 2019 − − − '''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med15&DO=10.1111%2fpan.13444 The effect of xenon-augmented sevoflurane anesthesia on intraoperative hemodynamics and early postoperative neurocognitive function in children undergoing cardiac catheterization: A randomized controlled pilot trial.]''' − − Source − Paediatric Anaesthesia. 28(8):726-738, 2018 08. − − Authors − Devroe S; Lemiere J; Van Hese L; Gewillig M; Boshoff D; Poesen K; Van de Velde M; Rex S − − Abstract − BACKGROUND: In adults, xenon has only minimal hemodynamic side effects when compared with other anesthetics. Moreover, in preclinical experiments, xenon has been demonstrated to possess cardio- and neuroprotective properties. Altogether, the favorable hemodynamic profile combined with its potential for organ-protection could render xenon an attractive option for anesthesia in children with cardiovascular compromise. − − AIMS: The aim of this study was to explore safety and feasibility of sevoflurane-augmented xenon anesthesia in school-aged children and to assess early postoperative neurocognitive effects of xenon-sevoflurane and sevoflurane anesthesia when compared to a control group that did not have anesthesia. − − METHODS: Forty children aged 4-12 years, suffering from congenital heart disease, undergoing diagnostic or interventional cardiac catheterization were randomized to either xenon-augmented sevoflurane anesthesia or sevoflurane alone. Safety was assessed by the incidence of intraprocedural hemodynamic instability and feasibility by anesthetic depth and respiratory profile. In addition, neurocognitive performance was assessed preoperatively, 2 hours after discharge from PACU and at 24 hours after anesthesia using the Amsterdam Neuropsychological Tasks system. A healthy control group of 22 age- and gender-matched children not exposed to anesthesia underwent an identical neurocognitive test battery, at comparable time intervals. − − RESULTS: Overall hemodynamics did not differ between groups. Xenon-sevoflurane anesthesia resulted in decreased intraoperative ephedrine requirements (median [IQR]) (0.00 mg/kg [0.00-0.00] vs 0.00 mg/kg [0.00-0.01], P = 0.047). Only neurocognitive tests in the domain of alertness were significantly impaired 2 hours postoperatively in both anesthesia groups in comparison with the control group (alertness variability: P = 0.02, odds ratio 5.8), but recovered at 24 hours. For working memory, inhibition, cognitive flexibility, and motor coordination tasks, no significant interaction effects of anesthesia were found in the early postoperative period. − − CONCLUSION: In this pilot trial, xenon-augmented sevoflurane anesthesia in school-aged children was feasible, and associated with decreased ephedrine requirements. All children exposed to anesthesia showed impaired neurocognitive performance in the immediate postoperative period when compared to control children; however, without significant differences between both treatment groups. Copyright © 2018 John Wiley & Sons Ltd. − − Publication Type − Clinical Trial, Phase II. Journal Article. Randomized Controlled Trial. Research Support, Non-U.S. Gov't. − − Year of Publication − 2018 − '''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med14&DO=10.1111%2fpan.13230 Xenon as an adjuvant to sevoflurane anesthesia in children younger than 4 years of age, undergoing interventional or diagnostic cardiac catheterization: A randomized controlled clinical trial.]'''+ − − Source − Paediatric Anaesthesia. 27(12):1210-1219, 2017 Dec. − − Authors − Devroe S; Meeusen R; Gewillig M; Cools B; Poesen K; Sanders R; Rex S − − Abstract − BACKGROUND: Xenon has repeatedly been demonstrated to have only minimal hemodynamic side effects when compared to other anesthetics. Moreover, in experimental models, xenon was found to be neuroprotective and devoid of developmental neurotoxicity. These properties could render xenon attractive for the anesthesia in neonates and infants with congenital heart disease. However, experience with xenon anesthesia in children is scarce. − − AIMS: We hypothesized that in children undergoing cardiac catheterization, general anesthesia with a combination of sevoflurane with xenon results in superior hemodynamic stability, compared to sevoflurane alone. − − METHODS: In this prospective, randomized, single-blinded, controlled clinical trial, children with a median age of 12 [IQR 3-36] months undergoing diagnostic/interventional cardiac catheterization were randomized to either general anesthesia with 50-65vol% xenon plus sevoflurane or sevoflurane alone. The primary outcome was the incidence of intraprocedural hemodynamic instability, defined as the occurrence of: (i) a heart rate change >20% from baseline; or (ii) a change in mean arterial blood pressure >20% from baseline; or (iii) the requirement of vasopressors, inotropes, chronotropes, or fluid boluses. Secondary endpoints included recovery characteristics, feasibility criteria, and safety (incidence of emergence agitation and postoperative vomiting. − − RESULTS: After inclusion of 40 children, the trial was stopped as an a priori planned blinded interim analysis revealed that the overall rate of hemodynamic instability did not differ between groups [100% in both the xenon-sevoflurane and the sevoflurane group. However, the adjuvant administration of xenon decreased vasopressor requirements, preserved better cerebral oxygen saturation, and resulted in a faster recovery. Xenon anesthesia was feasible (with no differences in the need for rescue anesthetics in both groups). − − CONCLUSION: Our observations suggest that combining xenon with sevoflurane in preschool children is safe, feasible, and facilitates hemodynamic management. Larger and adequately powered clinical trials are warranted to investigate the impact of xenon on short- and long-term outcomes in pediatric anesthesia. Copyright © 2017 John Wiley & Sons Ltd. − − Publication Type − Journal Article. Randomized Controlled Trial. − − Year of Publication − 2017 − − Line 94:
Line 38: − − Year of Publication − 2017 − '''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med13&DO=10.1016%2fj.jclinane.2015.10.018 Comparison of recovery parameters for xenon versus other inhalation anesthetics: systematic review and meta-analysis. [Review]]'''+ − − Source − Journal of Clinical Anesthesia. 29:65-74, 2016 Mar. − − Authors − Hou B; Li F; Ou S; Yang L; Zhou S − − Abstract − STUDY OBJECTIVE: To summarize and evaluate the available data describing the recovery parameters of xenon anesthesia. − − DESIGN: Systematic review and meta-analysis. − − SETTING: Anesthesia for elective surgeries. − − PATIENTS: Systematic review of randomized controlled trials (RCTs) from databases including Medline (1964-2013), the Cochrane Central Register of Controlled Trials (CENTRAL, 1990-2012), and Google Scholar (1966-2013). − − INTERVENTIONS: Inhalation of xenon or other anesthetics was administered in elective surgery. − − MEASUREMENTS: Recovery parameters (time to recovery, alertness/sedation scale scores at "eye opening," bispectral index at "reaction on demand," time to extubation, and time to orientation). − − MAIN RESULTS: Eleven RCTs (N = 661 patients) met the inclusion criteria. Recovery from xenon anesthesia was significantly faster in terms of the time to eye opening (mean difference [MD], -4.18 minutes; 95% confidence interval [CI], -5.03 to -3.32 minutes; P < .00001), the time to reaction on demand (MD, -5.35 minutes; 95% CI, -6.59 to -4.11 minutes; P < .00001), the time to extubation (MD, -4.49 minutes; 95% CI, -5.40 to -3.58 minutes; P < .00001), and the time to orientation (MD, -4.99 minutes; 95% CI, -6.45 to -3.52 minutes; P < .00001). − − CONCLUSIONS: This meta-analysis confirmed that recovery from xenon anesthesia is faster than other inhalation anesthesia. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved. − − Publication Type − Comparative Study. Journal Article. Meta-Analysis. Research Support, Non-U.S. Gov't. Review. Systematic Review. − − Year of Publication − 2016 − − Line 160:
Line 70: − Year of Publication − 2012 − '''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med9&DO=10.1016%2fj.neuroscience.2012.03.063 Xenon-induced inhibition of synchronized bursts in a rat cortical neuronal network.]'''+ − − Source − Neuroscience. 214:149-58, 2012 Jul 12. − − Authors − Uchida T; Suzuki S; Hirano Y; Ito D; Nagayama M; Gohara K − − Abstract − Xenon (Xe) and other inert gases produce anesthesia via an inhibitory mechanism in neuronal networks. To better understand this mechanism, we measured the electrical signals from cultured rat cortical neuronal networks in a multi-electrode array (MEA) under an applied Xe pressure. We used the MEA to measure the firing of the neuronal network with and without Xe gas pressurized to 0.3MPa. The MEA system monitored neuronal spikes on 16 electrodes (each 50x50mum(2)) at a sampling rate of 20kHz. The embryo rat cortical cells were first cultured on MEAs without Xe for approximately 3weeks, at which time they produced synchronized bursts that indicate maturity. Then, with an applied Xe pressure, the synchronized bursts quickly ceased, whereas single spikes continued. The Xe-induced inhibition-recovery of neuronal network firing was reversible: after purging Xe from the system, the synchronized bursts gradually resumed. Thus, Xe did not inhibit single neuron firing, yet reversibly inhibited the synaptic transmission. This finding agrees with the channel-blocker and a modified-hydrate hypothesis of anesthesia, but not the lipid-solubility hypothesis. Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved. − − Publication Type − Journal Article. Research Support, Non-U.S. Gov't. − − Year of Publication − 2012 − − − Line 201:
Line 91: − Year of Publication − 2010 − + − Line 225:
Line 112: − Year of Publication − 2007 − + Line 239:
Line 124: − Year of Publication − 1974 − + Line 252:
Line 135: − − Year of Publication − 1971
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1 Xenon/ (4750)
1 Xenon/ (4750)
2 Recycling/ (7025)
2 Recycling/ (7025) OR harvesting.mp. (54413) OR recapture.mp. (5204) OR capture.mp. (172877) OR recovery.mp. (624609)
3 1 and 2 (119)
4 from 3 keep 15,19,37,51,57,111,115 (7)
Xenon/ and (Recycling/ or harvesting.mp. or recapture.mp. or capture.mp. or recovery.mp.)
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'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fanie.201909544 Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics. [Review]]'''
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med16&DO=10.1002%2fanie.201909544 (15) Xenon Recovery by DD3R Zeolite Membranes: Application in Anaesthetics. [Review]]'''
Source
Source
Journal Article. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S.. Review.
Journal Article. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S.. Review.
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med14&DO=10.1002%2fchem.201700389 (19) Tunable Porous Coordination Polymers for the Capture, Recovery and Storage of Inhalation Anesthetics.]'''
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med14&DO=10.1002%2fchem.201700389 Tunable Porous Coordination Polymers for the Capture, Recovery and Storage of Inhalation Anesthetics.]'''
Source
Source
Publication Type
Publication Type
Journal Article.
Journal Article.
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med9&DO=10.1097%2fEJA.0b013e3283583c4b (37) A xenon recirculating ventilator for the newborn piglet: developing clinical applications of xenon for neonates.]'''
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med9&DO=10.1097%2fEJA.0b013e3283583c4b A xenon recirculating ventilator for the newborn piglet: developing clinical applications of xenon for neonates.]'''
Source
Source
Journal Article. Research Support, Non-U.S. Gov't.
Journal Article. Research Support, Non-U.S. Gov't.
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&DO=10.1213%2fANE.0b013e3181be0e17 (51) Closed-circuit xenon delivery using a standard anesthesia workstation.]'''
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med8&DO=10.1213%2fANE.0b013e3181be0e17 Closed-circuit xenon delivery using a standard anesthesia workstation.]'''
Source
Source
Journal Article.
Journal Article.
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&DO=10.1213%2f01.ane.0000278148.56305.72 (57) A cryogenic machine for selective recovery of xenon from breathing system waste gases.]'''
'''[ https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med6&DO=10.1213%2f01.ane.0000278148.56305.72 A cryogenic machine for selective recovery of xenon from breathing system waste gases.]'''
Source
Source
Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
Comparative Study. Journal Article. Research Support, Non-U.S. Gov't.
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med1&DO=10.1007%2fBF02477814 A recovery system for hyperbaric xenon.]'''
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med1&DO=10.1007%2fBF02477814 (111) A recovery system for hyperbaric xenon.]'''
Source
Source
Journal Article.
Journal Article.
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med1&DO=10.1016%2f0020-708x%2871%2990146-3 Recovery of 133 Xe from the expired gas in lung function studies.]'''
'''[https://login.liboff.ohsu.edu/login?url=http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=med1&DO=10.1016%2f0020-708x%2871%2990146-3 (115) Recovery of 133 Xe from the expired gas in lung function studies.]'''
Source
Source
Publication Type
Publication Type
Journal Article.
Journal Article.