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→10/2
==10/2==
==10/2==
*E-mailed slides to Nina and followed up on study. It is currently paused due to a bupivacaine shortage.
*E-mailed slides to Nina and followed up on study. It is currently paused due to a hyperbaric PF bupivacaine shortage at OHSU.
*Texted Brandon about which journals to submit to. '''1st choice: A&A, 2nd choice: Journal for Obstetric Anesthesia'''
*Texted Brandon about which journals to submit to. '''1st choice: A&A, 2nd choice: Journal for Obstetric Anesthesia'''
*Does TIVA prevent cancer recurrence? Head of Huntsman anesthesia did a cancer anesthesia fellowship and researched this a bit. Though he's now burned out on research, he's the guy to talk to about what's already been done or not.
*Does TIVA prevent cancer recurrence? Head of Huntsman anesthesia did a cancer anesthesia fellowship and researched this a bit. Though he's now burned out on research, he's the guy to talk to about what's already been done or not.
*Hamilton and I talked about why ketamine causes lasting changes in the brain long after the drug is gone. Is it a change to a gap junction network? '''Is it anti-inflammatory circulating EVs?'''. There are three papers on MedLine related to ketamine and EVs, none of which look (anti-)inflammatory molecules. Do circulating EVs after propofol anesthetic also contain the inflammatory cytokines that are seen after isoflurane?
*Hamilton and I talked about why ketamine causes lasting changes in the brain long after the drug is gone. Is it a change to a gap junction network? '''Is it anti-inflammatory circulating EVs?'''. There are three papers on MedLine related to ketamine and EVs, none of which look at (anti-)inflammatory molecules. Do circulating EVs after propofol anesthetic also contain the inflammatory cytokines that are seen after isoflurane?
===Mechanisms of Anesthesia===
==10/6==
*Pitched multi-centre trial to Brandon. E-mailed slides in .ppt format to Nina.
*Met w/ Norm about depression research and promotion requirements.
*Lit review of Yohimbine and Naloxone effects on EEG.
*Dug through supplement of 2026 A&A paper to find which anesthetics are most selective for which receptors.
*Thought about Jellyfish, Corral, Hydra
==Mechanisms of Anesthesia==
'''Big picture:''' understand the temporospatial and mechanistic changes in neural activity induced by various anesthetics. Can we recapitulate those with steerable, low latency, closed-loop non-invasive neuromodulation or use this knowledge to drive discovery of novel drugs?
'''Big picture:''' understand the temporospatial and mechanistic changes in neural activity induced by various anesthetics. Can we recapitulate those with steerable, low latency, closed-loop non-invasive neuromodulation or use this knowledge to drive discovery of novel drugs?
*High-throughput screen of anesthetics (and anesthetic reversal agents) in ''C.elegans''. I could work in parallel in a different organism (e.g. yeast, jellyfish, hydra, sea anemones, corral, bacteria, plants, neuronal explants).
*High-throughput screen of anesthetics (and anesthetic reversal agents) in ''C.elegans''. I could work in parallel in a different organism (e.g. yeast, jellyfish, hydra, sea anemones, corral, bacteria, plants, neuronal explants).
*What are the differences in mechanisms for amnesia, hypnosis, immobility, and analgesia?
*What are the differences in mechanisms for amnesia, hypnosis, immobility, and analgesia?
==CLAN==
===Alpha entrainment analgesia study===
**Successfully entrain alpha. What were we doing wrong? '''Is there anything in the literature that can guide a protocol modification?'''
**Successfully entrain alpha. What were we doing wrong? '''Is there anything in the literature that can guide a protocol modification?'''
**Can I incorporate withdrawal thresholds?
**Can I incorporate withdrawal thresholds?
**Power analysis based on pilot study
**Power analysis based on pilot study
**'''Systematic review and meta analysis'''
**'''Systematic review and meta analysis'''
===EEG effects of anesthetic agents===
Look at benzos, opioids, precedex, and their respective reversal agents. Also caffeine, methylphenidate, and methohexital. In MedLine, combine each agent with the search term Electroencephalography/ and add limits for Adults, Humans, and English. Which drugs are most target selective? What are their EEG effects?
Look at benzos, opioids, precedex, and their respective reversal agents. Also caffeine, methylphenidate, and methohexital. In MedLine, combine each agent with the search term Electroencephalography/ and add limits for Adults, Humans, and English. Which drugs are most target selective? What are their EEG effects?
*Yohimbine = 9
*Yohimbine = 9
*Caffeine = 138
*Caffeine = 138
==CO2==
*Does permissive hypercapnia improve hemodynamic stability, improve oxygen delivery to tissues, deepen anesthesia, and speed recovery?
*Does permissive hypercapnia improve hemodynamic stability, improve oxygen delivery to tissues, deepen anesthesia, and speed recovery?
==Depression==
*Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk of depression?
*Do ketamine, TIVA w/ propofol, TIVA w/ remimazolam, psychedelics, or burst suppression modulate the post-operative risk of depression?