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→10/14 Summary
**'''Read all about GABA receptors in Principles of Neural Science'''
**'''Read all about GABA receptors in Principles of Neural Science'''
**Optogenetics can control the activity of a genetically defined set of neurons to see if they are important for your topic of interest. e.g. express anion-conducting channelrhodopsins (ACRs, an inhibitory type of ChR) in α1β2γ2 GABA-R expressing neurons.
**Optogenetics can control the activity of a genetically defined set of neurons to see if they are important for your topic of interest. e.g. express anion-conducting channelrhodopsins (ACRs, an inhibitory type of ChR) in α1β2γ2 GABA-R expressing neurons.
***Could we use optogenetics to clarify whether certain non-canonical propofol targets receptors (e.g. α4β2 nAChR, HCN1) are necessary or sufficient for its effects?
***Could we use optogenetics to clarify whether certain non-canonical propofol target receptors (e.g. α4β2 nAChR, HCN1) are necessary or sufficient for its effects?
***Assuming that α1β2γ2 GABA<sub>A</sub>R is the critical receptor, can we demonstrate which circuits play a critical role? As a starting point (from Brown's Part I):
***Assuming that α1β2γ2 GABA<sub>A</sub>R is the critical receptor, can we demonstrate which circuits play a critical role? As a starting point (from Brown's Part I):
## Excitatory cortical pyramidal neurons
## Excitatory cortical pyramidal neurons