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→Mechanisms of Anesthesia
*'''Are there pharmacological agents with receptor specificity? When given together with "promiscuous" anesthetics, what happens? For instance, is propofol equally effective when given with a specific HCN1 receptor inhibitor? What about a GABA<sub>A</sub>R inhibitor?'''
*'''Are there pharmacological agents with receptor specificity? When given together with "promiscuous" anesthetics, what happens? For instance, is propofol equally effective when given with a specific HCN1 receptor inhibitor? What about a GABA<sub>A</sub>R inhibitor?'''
'''**Search [https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL63354/ ChEMBL]
**'''Search [https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL63354/ ChEMBL]
*'''Are there genetic KO/KD or optogenetic tools available for location-specific inducible receptor knockdowns?'''
*'''Are there genetic KO/KD or optogenetic tools available for location-specific inducible receptor knockdowns?'''
**Is the receptor, its components, or homologues of the gene expressed in different model organisms? What is the sequence similarity?
**Is the receptor, its components, or homologues of the gene expressed in different model organisms? What is the sequence similarity?