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Line 2:
Line 2: − + − + − * Widespread micro and macrovascular thrombosis, depletion of fibrinogen and fibrin clot formation+ − * Platelets are trapped in the clots −
→Pathogenesis
* '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
* '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
=Pathogenesis=
=Pathogenesis=
* Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)
* '''Exposure''': Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)
* Consumption of clotting factors
* '''Coagulation''': Consumption of clotting factors; Widespread micro and macrovascular thrombosis, depletion of fibrinogen and fibrin clot formation; Platelets are trapped in the clots
* '''Fibrinolysis''': Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]] such as D-dimer. Leads to worsened bleeding.
* Plasminogen --> Plasmin also upregulated, leading to large increase in clot breakdown and release of [[FDPs]] such as D-dimer.
=Diagnostic Algorithm=
=Diagnostic Algorithm=