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→Most Common Etiologies
=Most Common Etiologies=
=Most Common Etiologies=
* Top three etiologies: infection, malignancy, and trauma/surgery, each account for 10-20% of cases.
* '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
* '''Bacterial sepsis''' (83%), '''Trauma''' (31%), '''Cancer''' (e.g. APML, 6.8%), placental abruption, preeclampsia, amniotic fluid embolism, burn, hyperthermia, rhabdomyolysis, infection, transfusion reaction (ABO incompatibility), snake venom, aortic aneurysm
=Pathogenesis=
=Pathogenesis=
* '''Exposure''': Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)
* '''Exposure''': Expression of the transmembrane glycoprotein TF (which activates factor VII and the extrinsic pathway)