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→Mechanisms of Anesthesia
'''Big picture:''' understand the temporospatial and mechanistic changes in neural activity induced by various anesthetics. Can we recapitulate those with steerable, low latency, closed-loop non-invasive neuromodulation or use this knowledge to drive discovery of novel drugs?
'''Big picture:''' understand the temporospatial and mechanistic changes in neural activity induced by various anesthetics. Can we recapitulate those with steerable, low latency, closed-loop non-invasive neuromodulation or use this knowledge to drive discovery of novel drugs?
*High-throughput screen of anesthetics (and anesthetic reversal agents) in ''C.elegans''. I could work in parallel in a different organism (e.g. yeast, jellyfish, hydra, sea anemones, corral, bacteria, plants, neuronal explants).
*High-throughput screen of anesthetics (and anesthetic reversal agents) in ''C.elegans''. I could work in parallel in a different organism (e.g. yeast, jellyfish, hydra, sea anemones, corral, bacteria, plants, neuronal explants).
*Downsides of using 'weird' organisms is that there are relatively few genetic tools, antibodies, sparse literature, and few experts to consult.
*'''Has anyone published behavioral assays for these organisms? Detailed protocols for breeding them? Have they already been anesthetized?'''
*'''Has anyone published behavioral assays for these organisms? Detailed protocols for breeding them? Have they already been anesthetized?'''