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Adrenergic Pharmacology (view source)
Revision as of 23:08, 1 February 2023
, 23:08, 1 February 2023no edit summary
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists
|-
|-
| α1 || Norepi > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG
| α1 || NE > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG
|
|
*Norepi
*NE
*Phenylephrine
*Phenylephrine
*Midodrine
*Midodrine
*Tamsulosin
*Tamsulosin
|-
|-
| α2 || Epi = Norepi >> Iso || Mixed effects || Gi, presynaptic, cAMP down
| α2 || Epi = NE >> Iso || Mixed effects || Gi, presynaptic, cAMP down
|
|
*Dexmedetomidine
*Dexmedetomidine
*Trazodone
*Trazodone
|-
|-
| β1 || Iso > Norepi > Epi || Chronotropy, Inotropy, Amylase secretion || Gs, cAMP up
| β1 || Iso > NE > Epi || Chronotropy, Inotropy, Amylase secretion || Gs, cAMP up
|
|
*Dobutamine
*Dobutamine
*Esmolol
*Esmolol
|-
|-
| β2 || Iso > Epi > Norepi || Smooth muscle relaxation || Gs, cAMP up
| β2 || Iso > Epi > NE || Smooth muscle relaxation || Gs, cAMP up
|
|
*Albuterol
*Albuterol
*Labet'''alol''' (anti-α1)
*Labet'''alol''' (anti-α1)
|-
|-
| β3 || Iso > Epi = Norepi || Lipolysis, bladder detrusor relaxation || Gs, cAMP up
| β3 || Iso > Epi = NE || Lipolysis, bladder detrusor relaxation || Gs, cAMP up
|
|
*Mirabegron
*Mirabegron