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Adrenergic Pharmacology (view source)
Revision as of 06:07, 4 February 2023
, 06:07, 4 February 2023no edit summary
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists
! Receptor !! Binding Affinity !! Effects !! Mechanism !! Agonists !! Antagonists
|-
|-
| α1 || NE > Epi >> Iso || Smooth muscle contraction || Gq, PLC -> IP3/DAG
| α1 || NE > Epi >> Iso
|
*Smooth muscle contraction, ↑SVR, ↑MAP
*Mydriasis, urethral sphincter contraction
|
G<sub>q</sub> → PLC → IP<sub>3</sub>/DAG → [Ca<sup>2+</sup>]<sub>i</sub>
|
|
*NE
*NE
*Phenylephrine
*Phenylephrine (pure α1)
*Midodrine
*Midodrine
|
|
*Tamsulosin
*Tamsulosin
|-
|-
| α2 || Epi = NE >> Iso || Mixed effects || Gi, presynaptic, cAMP down
| α2 || Epi = NE >> Iso
|
*↑SVR, ↑MAP
*Decreased insulin release, inhibits lipolysis, decreases aqueous humor production
|
presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → inhibition of NT release, sympatholytic effects
|
|
*Dexmedetomidine
*Dexmedetomidine
*Trazodone
*Trazodone
|-
|-
| β1 || Iso > NE > Epi || Chronotropy, Inotropy, Amylase secretion || Gs, cAMP up
| β1 || Iso > NE > Epi
|
*↑Chronotropy (myocytes), ↑Inotropy (SA node) →↑CO
*↑Renin release/↑volume (JGA)
*Amylase secretion
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G<sub>s</sub> → ↑AC → ↑cAMP
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|
*Dobutamine
*Dobutamine