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Adrenergic Pharmacology (view source)
Revision as of 06:14, 4 February 2023
, 06:14, 4 February 2023no edit summary
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*↑SVR, ↑MAP
*↑SVR, ↑MAP
*Decreased insulin release, inhibits lipolysis, decreases aqueous humor production
*↓insulin release, ↓lipolysis, ↓aqueous humor production
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presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → inhibition of NT release, sympatholytic effects
presynaptic G<sub>i</sub> → ↓AC → ↓cAMP → ↓NT release, sympatholytic effects
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*Dexmedetomidine
*Dexmedetomidine
| β1 || Iso > NE > Epi
| β1 || Iso > NE > Epi
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*↑Chronotropy (myocytes), ↑Inotropy (SA node) →↑CO
*↑Chronotropy (myocytes), ↑Inotropy (SA node), ↑SBP
*↑Renin release/↑volume (JGA)
*↑Renin release/↑volume (JGA)
*Amylase secretion
*Amylase secretion
*Esmolol
*Esmolol
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| β2 || Iso > Epi > NE || Smooth muscle relaxation || Gs, cAMP up
| β2 || Iso > Epi > NE
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*Smooth muscle relaxation, ↓SVR, ↓DBP, ↓MAP
*Bronchodilation
*↑Lipolysis, ↑Insulin release
*Relax uterine smooth muscle
*↑aqueous humor production
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G<sub>s</sub> → ↑cAMP → ↑PKA
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*Albuterol
*Albuterol